Pap Pulmonary Alveolar Proteinosis

Therapy Options In pulmonary alveolar proteinosis
Pulmonary alveolar proteinosis (PAP) is a rare condition characterized by the accumulation of lipoproteinaceous material within the airspaces, resulting in impaired gas transfer of various degrees of severity, and clinical manifestations ... Document Viewer

Whole Lung Lavage Therapy For pulmonary alveolar proteinosis ...
Used to treat pulmonary alveolar proteinosis (PAP), a rare syndrome occurring in a heterogeneous group of lung diseases characterized by accumulation of lipopro-teinaceous material in the alveoli, whicht impairs oxygen uptake and causes hypoxemic respiratory failure [2, 3]. ... Fetch Doc

Inhaled GM-CSF In A Pulmonary Alveolar Proteinosis Patient ...
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterized by the accumulation of surfactant proteins and lipids within the alveoli, which is caused by a defective macrophage catabolism, due to a disruption in surfactant homeostasis [1]. ... Retrieve Here

Pulmonary Alveolar Proteinosis: Determination Of ...
Formed by alveolar macrophages. Key words: Leukotrienes--Prostaglandins--Pulmonary alveolar proteino- sis--Lavage fluid. Introduction In pulmonary alveolar proteinosis (PAP), proteinlike material is accumulated in the alveoli. This leads to impaired gas exchange in the alveoli and a decreased lung capacity. ... Doc Viewer

Heterozygous Mutations In OAS1 Cause Infantile-Onset ...
Pulmonary alveolar proteinosis (PAP) is characterized by accumulation of a surfactant-like substance in alveolar spaces and hypoxemic respiratory failure. Genetic PAP (GPAP) is caused by mutations in genes encoding surfactant proteins or genes encoding a surfactant phospholipid transporter in alveolar type II epithelial cells. ... Retrieve Content

Case Report Alveolar proteinosis In Extremis: A Critical Case ...
Pulmonary alveolar proteinosis (PAP) is a syn-drome arising from altered surfactant homeo-stasis. Pathophysiologically, the major changes involve impaired pulmonary diffusion and venti - lation/perfusion mismatch, which may result in ... View Doc

Pulmonary alveolar proteinosis: Four Cases* - SciELO
Pulmonary alveolar proteinosis (PAP) is a disease characterized by the build-up of lipoprotein material inside the alveoli, significantly interfering with pulmonary gas exchange. It is a rare disorder, with an estimated prevalence of 0.37 cases for every 100,000 people. (1) First described in 1958(2), the etiology of PAP remains obscure. ... Visit Document

Vocal Cord Paresis - Wikipedia
Vocal fold paresis, also known as recurrent laryngeal nerve paralysis or vocal fold paralysis, is the medical term describing an injury to one or both recurrent laryngeal nerves (RLNs), which control all muscles of the larynx except for the cricothyroid muscle.The RLN is important for speaking, breathing and swallowing. ... Read Article

Inhaled Granulocyte/Macrophage–Colony Stimulating Factor As ...
Pulmonary alveolar proteinosis (PAP) showed that inhaled GM-CSF is promising as therapy for PAP. What This Study Adds to the Field This national, multicenter study demonstrates that inhaled GM-CSF therapy of PAP is safe, efficacious, and provides a durable treatment effect in many patients. ... Fetch Full Source

Pulmonary Alveolar Proteinosis: An Overview For Internists ...
Pulmonary alveolar proteinosis (PAP) is a relatively rare clinicopathological entity with an estimated annual incidence of 0.36 and a prevalence of 3.7 per million popula- tion in the United States and internationally. 1,2 This usually manifests as a diffuse lung ... Access Full Source

Glycosaminoglycans And Glycoproteins In Bronchoalveolar ...
Alveolar lavage fluid may be related to the prognosis of pulmonary alveolar proteinosis. INTRODUCTION Pulmonary alveolar proteinosis (PAP) is characterized by deposition in alveoli of proteinaceous materials which stain pink with eosin and are strongly positive to periodic acid-Schiff (PAS) stain (1). ... Retrieve Document

New Interplay Between Interstitial And alveolar Macrophages ...
Including pulmonary alveolar proteinosis (PAP). The mechanisms of this lung toxicity remain unknown. Here, we reveal the respective roles of resident alveolar (Siglec-F high AM) and recruited interstitial (Siglec-F low IM) macrophages contributing in concert to the development of PAP. ... View Full Source

Laryngotracheal Stenosis - Wikipedia
Laryngotracheal stenosis is an umbrella term for a wide and heterogeneous group of very rare conditions. The population incidence of adult post-intubation laryngotracheal stenosis which is the commonest benign sub-type of this condition is approximately 1 in 200,000 adults per year. [10] ... Read Article

Pulmonary alveolar proteinosis | Full Lung Lavage | Surgery ...
Surgery video of a full lung lavage to clear Pulmonary alveolar proteinosis. first time performed at papworth hospital in 20 years 30 people in the uk suffer from this condition making it 1 in 2 ... View Video

PULMONARY ALVEOLAR PROTEINOSIS - ResearchGate
Pulmonary alveolar proteinosis is a rare disease but an important diagnosis to make as treatment with pulmonary lavage is curative in a large proportion of patients. Key-word: Lung, diseases. ... Fetch Full Source

Aerosolized GM-CSF Ameliorates pulmonary alveolar proteinosis ...
That of the human disease known as pulmonary alveo-lar proteinosis (PAP). Pulmonary surfactant is a com-plex mixture of phospholipids and SP-A, -B, -C, and -D, which are synthesized and secreted primarily by alveo-lar type II epithelial cells (29). Approximately 80% of alveolar surfactant is cleared by type II cells, which ... Doc Retrieval

Pulmonary alveolar proteinosis Secondary To Chronic Chlorine ...
Pulmonary Alveolar Proteinosis (PAP) is one of the “orphan diseases” of the lung, whose peculiarity consists in an intra-alveolar accumulation of a lipo-proteinaceous material related to surfactant, which interferes with gas exchange, presenting with symptoms and signs varying in intensity. Initially ... Content Retrieval

Primary pulmonary alveolar proteinosis - DoiSerbia
Pulmonary alveolar proteinosis (PAP) is an uncommon disease characterized by the accumulation of surfactant pro-teins and phospholipids within the alveolar spaces 1. Acquired PAP can be idiopathic (primary) PAP and secondary PAP. Secondary PAP is associated with hemato- ... Return Document

Long-term Follow-up And Treatment Of Congenital alveolar ...
Keywords: pulmonary alveolar proteinosis, therapeutic lung lavage, GM-CSF-R alpha, genetic defect, stop codon Background Pulmonary alveolar proteinosis (PAP) is characterized by a substantial and persistent increase in surfactant pool size [1,2]. There are several causes of this rare condition; mouse models with deletion of granulocyte-macrophage- ... View This Document

Pulmonary Alveolar Proteinosis And Tuberculosis In A ... - SciELO
A case of Pulmonary Alveolar Proteinosis (PAP), in association with tuberculosis, is described in a 35-year-old diabetic patient. Lung biopsy showed an intra-alveolar accumulation of PAS-positive material, and multifocal granulomas compatible with tuberculosis. The bronchoalveolar culture was positive for Mycobacterium tuberculosis. ... Fetch Document

Pulmonary Alveolar Proteinosis - Link.springer.com
Pulmonary alveolar proteinosis (PAP) is a rare and fascinating tors have postulated a decreased clearance of surfactant from the lung disease that is characterized by the accumulation of li- alveoli. Important advances have been made in our understanding ... Read Document

Pulmonary Alveolar Proteinosis, eine Lungenerkrankung, siehe Alveolarproteinose Technik: Password Authentication Protocol , ein Verfahren zur Authentifizierung über das Point-to-Point Protocol ... Read Article

Pulmonary Alveolar Proteinosis - JAMA Internal Medicine
Pulmonary Alveolar Proteinosis James B. McClenahan, MD, Rowena Mussenden, Palo Alto, Calif Intra-alveolar material from three patients with pulmonary alveolar proteinosis (PAP) who underwent therapeutic pulmonary la- vage was studied to determine its composi- tion and surface properties. This material was compared with material lavaged from ... Read Here